Aim1: Characterize CIMP phenotype in colon cancer using the 450k arrays

–Identify patient groups in relation to characteristic DNA methylation signature (CIMP)

–Where does it occur? CpG islands/shores/shelves

–Any correlation with ~~overall survival/presence of (no information available)~~ metastasis, tumor stage, lymphocyte invasion

–Methods: comethylation networks and clustering

Aim2: Characterize CIMP phenotype in relation to the gene mutations

- All genes with the focus on the known players such as KRAS and BRAF

-Focus on epigenes (EZH2, DNMT, etc)

-Casual relationship between mutations and CIMP (what comes first)

Aim3: Compare rectal and colon cancer in relation to CIMP (as 450k array data for READ arrive?)

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