Laird (2006, 2011) markers

Laird (2006, 2011) markers

In contrast to Shen, 2007 paper Weisenberger, 2006 identified a smaller set of markers: CACNA1G, IGF2, NEUROG1, RUNX3, SOCS1 and MLH1 as CIMP in colorectal patients. These markers were also confirmed in Hinoue, 2011 paper. In 2006 paper they weren't able to confirm Shen's markers.

CpGs mapped to the 5 genes on 27 k platform:

probe_id gene_id symbol 5524 cg05942574 8913 CACNA1G 10454 cg11262815 8913 CACNA1G 17291 cg18454685 8913 CACNA1G 4594 cg04897683 4762 NEUROG1 10437 cg11248413 4762 NEUROG1 16710 cg17830308 4762 NEUROG1 5592 cg06037693 864 RUNX3 12515 cg13461622 864 RUNX3 13229 cg14182690 864 RUNX3 15532 cg16529592 864 RUNX3 457 cg00487159 8651 SOCS1 5834 cg06295404 8651 SOCS1 24322 cg26012103 8651 SOCS1 24608 cg26301908 8651 SOCS1 3722 cg03956628 4292 MLH1 10187 cg10990993 4292 MLH1 22991 cg24607398 4292 MLH1