Mouse Models

This page describes the procedure for how MODEL-AD teams should submit mouse models to the DCC. The mouse models will be posted on the experimental tools page on the AD Knowledge Portal.

Step 1: Submit Mouse Model details

Please provide information about the mouse model in this MODEL-AD Tools survey. The strain information should match that on the JAX stock page.

• Email address of the person submitting the survey

• Grant number

• Species

• Model system name (see names in the AD Metadata Dictionary)

• Model URL to Jax stock page (ex: https://www.jax.org/strain/031988)

• Report card URL to AlzForum research model (ex: https://www.alzforum.org/research-models/3xtg)

• Model description (<500 characters)

• List of genes the model is targeting

• Background strain (eg, C57BL/6J)

• Type (LOAD – Late Onset Alzheimer’s Disease, FAD – Familial Alzheimer’s Disease)

• At the bottom of the survey, you can upload a PDF of the Mouse Model Report. The AD-DCC will add it to the Mouse Model Reports in Synapse.

Open

Example report

Step 2: Model added to the Portal

The DCC creates a new entity in Synapse’s Experimental Tools named after the Model System Name. This entity will be annotated with the information provided, including a link to the JAX stock page, and a list of studies that include data from the model.

The DCC will add the PDF report to the Mouse Model Reports in Synapse. Since the mouse model reports do not include sensitive information or PII/PHI, they are eligible for anonymous viewing and download permissions in Synapse. The Sage Governance team is responsible for enabling sharing permissions for each file in Synapse.

Open

Tools listed in Synapse

Step 3: Community Update

The DCC informs the community when a new model is available on the Portal in the AD Knowledge Portal News. See past Public Data Release Notes.