Contributing Mouse Model Information

This article describes the procedure for how MODEL-AD teams should submit new mouse model information to the Sage Data Coordination Center (DCC). Information about the model will be posted on the experimental tools page on the AD Knowledge Portal.

Step 1: Submit model information through survey

Please provide information about the mouse model in this MODEL-AD Tools survey. The strain information should match that on the JAX stock page.

• Email address of the person submitting the survey

• Grant number

• Species

• Model system name (see names in the AD Metadata Dictionary)

• Model URL to Jax stock page (ex: https://www.jax.org/strain/031988)

• Report card URL to AlzForum research model (ex: https://www.alzforum.org/research-models/3xtg)

• Model description (<500 characters)

• List of genes the model is targeting

• Background strain (eg, C57BL/6J)

• Type (LOAD – Late Onset Alzheimer’s Disease, FAD – Familial Alzheimer’s Disease)

• At the bottom of the survey, you can upload a PDF of the mouse model report. The AD-DCC will add it to the Mouse Model Reports in Synapse.

Step 2: DCC adds model to the AD Knowledge Portal

• The DCC creates a new entity in Synapse’s Experimental Tools. This will be named after the Model Common Name and will link to the JAX lab stock page.

• The DCC annotates the new model with the content provided in the survey.

• The DCC creates a link to any study that includes data from the model.

• The AD-DCC will add the report into the Mouse Model Reports in Synapse. Since the mouse model reports do not include sensitive information or PII/PHI, they are eligible for anonymous viewing and download permissions in Synapse. The Sage Governance team is responsible for enabling sharing permissions for each file in Synapse.

• Sage DCC updates file view with a link to the mouse model report in the Experimental Tools

Step 3: Creating release notes and advertising new models

The DCC writes release notes to inform the community when a new model is available. The release notes are posted in AD Knowledge Portal News and link to the experimental tool in the AD Knowledge portal.

FUTURE DIRECTION: When a new model is made available, the DCC will write a feature story about it for the newsletter. See past AD Knowledge Portal Public Data Release Notes.