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Genotypes

These are the variables describing the mice in the Individual Metadata file. The modelSystemName is used as file annotation. The AD Model Explorer uses the LOAD definition.

Variable

Definition

Example

officialName

Full name indicating all transgenes, taken from the strain’s Jax datasheet

B6.Cg-Apoetm1.1(APOE*4)Adiuj Abca7em2Adiuj Trem2em1Adiuj/J

modelSystemName

Strain annotation - see AMP-AD Metadata Dictionary. Used as file annotation

Abca7A1527GAPOE4Trem2R47H

stockNumber

The Jax stock number

030283

genotypeBackground

Background genotype

C57BL6J

genotype

Genotype of animal that indicates littermate carriers vs noncarriers

APOE4_homozygous; TREM2R47H_homozygous; ABCA7KI_NONCARRIER

APOE4_homozygous; TREM2R47H_homozygous; ABCA7KI_HOMOZYGOUS

individualCommonGenotype

Genotype of animal that includes LOAD1 or LOAD2 terminology. This is the model name used in the AD Model Explorer

LOAD1= APOE4_HOMOZYGOUS; TREM2R47H_HOMOZYGOUS. LOAD2=APOE4_HOMOZYGOUS; TREM2R47H_HOMOZYGOUS; ABETA_HOMOZYGOUS

LOAD1

LOAD1.ABCA7A1527G

modelCommonName

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