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Submitting MODEL-AD Experimental Tools

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Describe Mouse Model in MODEL-AD Tools Survey

This article will teach you how to submit new rodent models to the Data Coordination Center (DCC) at Sage Bionetworks. To start, MODEL-AD teams must inform the DCC about new models by submitting a complete and accurate description via the MODEL-AD Tools survey. The content entered into the survey will be used to populate the corresponding Experimental Tool card in the AD Knowledge Portal.

Metadata Key Variables

Mouse models must include the information listed below. The model information should match that on the Jackson labs stock pages, and any discrepancies will need to be resolved. If you have any questions, please contact the DCC before submitting.

  • Email address for contact person

  • Grant number

  • Species

  • Model Common Name

  • Model URL (link to the stock number in the Jackson Lab database)

  • Report card URL (link to the research model in ALZFORUM )

  • Model description (<500 characters)

  • Targeted Genes

  • Background strain

  • Type (Late Onset AD, Familial AD)

Create Model Entity in Experimental Tools

The Sage DCC will create a new entity in the AD Knowledge Portal’s Experimental Tools file view. The new entity will be named after the Model Common Name and will include a link to the corresponding Jackson labs Model URL webpage.

  1. Navigate to AD Knowledge Portal’s (File > Portal > ExperimentalTools) page

  2. Click Folder Tools > Add New Folder

  3. Name the folder with the Model Common Name

  4. Add a URL to the Jackson labs strain (eg, https://www.jax.org/strain/123456)

Annotate Model

Sage DCC adds annotations to folders using the using the file view.

  1. Navigate to the AD Knowledge Portal - backend > Portal - Experimental Tools

  2. Download the Portal - Experimental Tools

    1. Click Download Options > Export Table

    2. Click Download as CSV

  3. Add annotations to file

  4. Upload data to entity view to populate annotations

Link to Experimental Study

Sage DCC enters link to study with the data available for the model.

  • Note: Although not implemented yet, there has been a discussion about linking to a query of all data from the model instead of individual studies.

Create and share Model release notes

Sage DCC writes release notes to inform the community that a new model is available. The release notes must link to the Experimental Model card in the AD Knowledge portal.

Past release notes are available in this document.

MODEL-AD teams provide mouse model reports

MODEL-AD teams should provide a mouse model report in PDF format. See example here [add link]

Sage DCC will mouse model card in Synapse to this mouse model report.

For this information to be visible publicly, the DCC team must:

  • Create Jira ticket and assign to Director.

  • Once approved, the Jira ticket will be assigned to the Sage governance team who will set permissions as needed. The permissions for each file must be set at the file level rather than folder level.

Sage team links mouse model report

Sage DCC uploads reports to [MouseModelReports](https://www.synapse.org/#!Synapse:syn25474060 )

Sage DCC requests necessary permissions

Sage DCC requests that the PDF model report is permitted to be publicly available in Sage without restriction. [Enable Anonymous Download of Synapse Data](How to Enable Anonymous Download of Synapse Data )

Sage DCC updates file view with link to model report

Sage DCC updates file view with a link to the mouse model report in the [Portal - Experimental Tools](https://www.synapse.org/#!Synapse: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 )

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