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This page describes the procedure for how MODEL-AD
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This article will teach you how to submit new rodent teams should submit mouse models to the Data Coordination Center ( DCC) at Sage Bionetworks. To start, MODEL-AD teams must inform the DCC about new models by submitting a complete and accurate description via the [MODEL-AD Tools survey](https://docs.google.com/forms/d/e/1FAIpQLSfP0jZf_XZKP5Kqvf8GZbZgntCMAnAgDQww9e0jhsweqOYGqw/viewform). The content entered into the survey will be used to populate the corresponding Experimental Tool card in . The mouse models will be posted on the experimental tools page on the AD Knowledge Portal.
Metadata Key Variables
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Step 1: Submit Mouse Model details
Please provide information about the mouse model in this MODEL-AD Tools survey. The strain information should match that on the Jackson labs stock pages, and any discrepancies will need to be resolvedJAX stock page.
Email address for contact personof the person submitting the survey
Grant number
Species
Model Common Namesystem name (see names in the AD Metadata Dictionary)
Model URL (link to the Jax strain databaseJax stock page (ex: https://www.jax.org/strain/031988)
Report card URL (link to the AlzForumAlzForum research model (ex: https://www.alzforum.org/research-models/3xtg)
Model description (<500 characters)Targeted
GenesList of genes the model is targeting
Background strain (eg, C57BL/6J)
Type (LOAD – Late Onset ADAlzheimer’s Disease, FAD – Familial AD)
Create Experimental Study in Experimental Tools
The Sage DCC creates a dummy folder in the AD Knowledge Portal’s [Experimental Tools file view](https://www.synapse.org/#!Synapse:syn22219740)
Annotate the Experimental Study
Link to Experimental Study
Sage DCC enters link to study with data available on the model.
Sage DCC writes release notes to inform the community a new model is available.
MODEL-AD teams provide mouse model reports
Mouse model information should be provided in a PDF. Sage DCC will link to this PDF to the mouse model card in Synapse.
Create Jira ticket and assigned to Director. Once approved this will be assigned to the governance team to set permissions accurately for files. Some files will be publicly viewable and will need approval by the governance team to be allowed. This occurs at the file, not folder level.
Sage team links mouse model report
Sage DCC uploads reports to [MouseModelReports](https://www.synapse.org/#!Synapse:syn25474060 )
Sage DCC requests necessary permissions
Sage DCC requests that the PDF model report is permitted to be publicly available in Sage without restriction. [Enable Anonymous Download of Synapse Data](How to Enable Anonymous Download of Synapse Data )
Sage DCC updates file view with link to model report
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Alzheimer’s Disease)
At the bottom of the survey, you can upload a PDF of the Mouse Model Report. The AD-DCC will add it to the Mouse Model Reports in Synapse.
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Step 2: Model added to the Portal
The DCC creates a new entity in Synapse’s Experimental Tools named after the Model System Name. This entity will be annotated with the information provided, including a link to the JAX stock page, and a list of studies that include data from the model.
The DCC will add the PDF report to the Mouse Model Reports in Synapse. Since the mouse model reports do not include sensitive information or PII/PHI, they are eligible for anonymous viewing and download permissions in Synapse. The Sage Governance team is responsible for enabling sharing permissions for each file in Synapse.
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Step 3: Community Update
The DCC informs the community when a new model is available on the Portal in the AD Knowledge Portal News. See past Public Data Release Notes.