This article This page describes the procedure for how MODEL-AD teams should submit new mouse model information models to the Sage Data Coordination Center ( DCC). Information about the model . The mouse models will be posted on the experimental tools page on the AD Knowledge Portal.
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Step 1: Submit
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Mouse Model details
Please provide information about the mouse model in this MODEL-AD Tools survey. The strain information should match that on the JAX strain webpagestock page.
Email address (of the person submitting the survey)
Grant number
Species (eg, Mouse)Model Common Name as listed on the MODEL-AD Strain Table
Model system name (see names in the AD Metadata Dictionary)
Model URL to Jax strain stock page
(ex: https://www.jax.org/strain/031988)Report card URL to AlzForum strain
research model (ex: https://www.alzforum.org/research-models/3xtg)Model description (<500 characters)
List of genes the model is targeting
Background strain (eg, C57BL/6J)
Type (LOAD – Late Onset Alzheimer’s Disease, FAD – Familial Alzheimer’s Disease)
FUTURE DIRECTION: Submit mouse model report PDF. This report should be uploaded as one question in the survey. A new survey object will need to be created. At the bottom of the survey, you can upload a PDF of the Mouse Model Report. The AD-DCC will then add the strain report into add it to the Mouse Model Reports in Synapse.
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Step 2:
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Model added to the
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Portal
The DCC creates a new entity in Synapse’s Experimental Tools
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named after the Model
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System Name
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. This entity will be annotated with the information provided, including a link to the JAX
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The DCC annotates the new model with the content provided in the survey.
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stock page, and a list of studies that include data from the model.
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The
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DCC will add the PDF report
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to the Mouse Model Reports in Synapse. Since the mouse model reports do not include sensitive information or PII/PHI, they are eligible for anonymous viewing and download permissions in Synapse. The Sage Governance team is responsible for enabling sharing permissions for each file in Synapse.
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Step 3:
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Community Update
The DCC writes release notes to inform informs the community when a new model is available . The release notes are posted in on the Portal in the AD Knowledge Portal News and link to the experimental tool in the AD Knowledge portal. FUTURE DIRECTION: When a new model is made available, the DCC will write a feature story about it for the newsletter. See past AD Knowledge Portal Public Data Release Notes.
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