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This article page describes the procedure for how MODEL-AD teams should submit new strain information mouse models to the Data Coordination Center (AD- DCC). Information about each new strain . The mouse models will be posted on the experimental tools page on the AD Knowledge Portal.
Step 1:
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Submit Mouse Model details
Please provide information about the
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mouse model in this MODEL-AD
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Each strain should include the key details listed below. The model details should match the information on the Jax strain webpage, and any discrepancies will need to be resolvedTools survey. The strain information should match that on the JAX stock page.
Email address for of the person submitting the survey
MODEL-AD Grant number
Species
Model Common Name as listed on the MODEL-AD Strain Tablesystem name (see names in the AD Metadata Dictionary)
Model URL to Jax strain stock page (ex: https://www.jax.org/strain/031988)
Report card URL to AlzForum strain research model (ex: https://www.alzforum.org/research-models/3xtg)
Model description (<500 characters)
List of genes the model is targeting
Background strain (eg, C57BL/6J)
Type (LOAD – Late Onset Alzheimer’s Disease, FAD – Familial Alzheimer’s Disease)
MODEL-AD submits strain report
The MODEL-AD team should provide the AD-DCC with a new strain report PDF. This report should be uploaded for question number X of the survey.
At the bottom of the survey, you can upload a PDF of the Mouse Model Report. The AD-DCC will add it to the
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Step 2:
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Model added to the
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Portal
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The AD- DCC creates a new file entity in Synapse’s Experimental Tools for the strain. The entity is named after the Model Common System Name and will link to the Jax lab strain page.
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Annotate strain
The AD-DCC annotates the new strain with the content provided in the survey.
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Link to all data files from strain
The AD-DCC creates a link to any study that includes data from the strain.
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AD-DCC sets necessary sharing permissions
. This entity will be annotated with the information provided, including a link to the JAX stock page, and a list of studies that include data from the model.
The DCC will add the PDF report to the Mouse Model Reports in Synapse. Since the mouse model reports do not include sensitive information or PII/PHI, they are eligible for anonymous viewing and download permissions in Synapse. The Sage Governance team is responsible for enabling sharing permissions for each file in Synapse.
Sage DCC updates file view with link to model report
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Step 3:
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Community Update
The AD-DCC writes release notes to inform DCC informs the community when a new strain model is available . The release notes are posted in News stories and link to the experimental tool on the Portal in the AD Knowledge portal. Additionally, when a new strain is available the AD-DCC could write a feature story about it in the newsletter (**Discuss this option w/ MODEL-AD teams**).Past release notes are available in this documentPortal News. See past Public Data Release Notes.