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Variable

Definition

Value

genotype

Genotype of animal that indicates littermate carriers vs noncarriers.

Naming Format

Names derived from joining three Climb variables

:<gene>-<allele>_<genotype_symbol>
  • See complete list of acceptable values:

    Lref gdrive file
    urlhttps://docs.google.com/spreadsheets/d/1vRJ0SKHHaj61LpJ54nQQUyRWhuGFWgPcmbPuAAj4gZk/edit?usp=sharing

  • Genes

    • 5XFAD (transgene)

    • 3xTg (transgene)

    • APOE4

    • hAbeta

    • Trem2

    • Picalm

    • Bin1

    • Abca7

    • Spi1

    • Abi3

    • Clu

    • Epha1

  • Allele

    • KI

    • KO

    • FLX

    • Cre

    • 3xTg

    • R47h

    • GFP

    • Arc

    • Swe

    • Aus

    • Lon

    • Flo

    • Tg

    • KI_LoxP

    • M146V

    • R47H_NSS

    • H458R

    • K358R

    • V1599M

    • rs9331888nr

    • rs9331888

    • rs1377614

    • rs2279590_KI

    • S209F

    • rs243559662

    • P460L

  • Genotype Symbols

    • WT

    • heterozygous

    • homozygous

    • carrier (transgenes only)

    • noncarrier (transgenes only)

  • genotypeBackground

    Genetic background of the model

  • C57BL6J (#000664, JAX link)

  • C57BL6N (#005304

    in this specific format:

    gene-allele_genotype

    Expand
    titleMODEL-AD-approved Values

    3xTg-AD_carrier
    3xTg-AD_noncarrier
    5XFAD_carrier
    5XFAD_noncarrier
    Abca7-KI_heterozygous
    Abca7-KI_homozygous
    Abca7-KI_WT
    Abca7-KO_heterozygous
    Abca7-KO_homozygous
    Abca7-KO_WT
    Abca7-V1599M_heterozygous
    Abca7-V1599M_homozygous
    Abca7-V1599M_WT
    Abi3-S209F_heterozygous
    Abi3-S209F_homozygous
    Abi3-S209F_WT
    APOE2-KI_heterozygous
    APOE2-KI_homozygous
    APOE2-KI_WT
    APOE3-KI_heterozygous
    APOE3-KI_homozygous
    APOE3-KI_WT
    APOE4-KI_heterozygous
    APOE4-KI_homozygous
    APOE4-KI_WT
    APP 3&5_carrier
    APP 3&5_noncarrier
    APPswe_carrier
    APPswe_noncarrier
    B2M-KO_heterozygous
    B2M-KO_homozygous
    B2M-KO_WT
    Bin1-FLX_heterozygous
    Bin1-FLX_homozygous
    Bin1-FLX_WT
    Bin1-K358R_heterozygous
    Bin1-K358R_homozygous
    Bin1-K358R_WT
    Bin1-KI_heterozygous
    Bin1-KI_homozygous
    Bin1-KI_WT
    Bin1-KO_heterozygous
    Bin1-KO_homozygous
    Bin1-KO_WT
    C3-KO_heterozygous
    C3-KO_homozygous
    C3-KO_WT
    C5-D2_heterozygous
    C5-D2_homozygous
    C5-D2_WT
    C5-KO_heterozygous
    C5-KO_homozygous
    C5-KO_WT
    Cd2ap-KI_heterozygous
    Cd2ap-KI_homozygous
    Cd2ap-KI_WT
    Cd2ap-KO_heterozygous
    Cd2ap-KO_homozygous
    Cd2ap-KO_WT
    Ceacam1-KO_heterozygous
    Ceacam1-KO_homozygous
    Ceacam1-KO_WT
    Clasp2-KI_heterozygous
    Clasp2-KI_homozygous
    Clasp2-KI_WT
    Clasp2-KO_heterozygous
    Clasp2-KO_homozygous
    Clasp2-KO_WT
    Clu-KO_heterozygous
    Clu-KO_homozygous
    Clu-KO_WT
    Clu-rs2279590_KI_heterozygous
    Clu-rs2279590_KI_homozygous
    Clu-rs2279590_KI_WT
    Clu-rs9331888_heterozygous
    Clu-rs9331888_homozygous
    Clu-rs9331888_WT
    Clu-rs9331888nr_heterozygous
    Clu-rs9331888nr_homozygous
    Clu-rs9331888nr_WT
    CR1-KO_heterozygous
    CR1-KO_homozygous
    CR1-KO_WT
    CR1-long_heterozygous
    CR1-long_homozygous
    CR1-long_WT
    CR1-short_heterozygous
    CR1-short_homozygous
    CR1-short_WT
    CR2CR1_heterozygous
    CR2CR1_homozygous
    CR2CR1_WT
    Cx3cr1_heterozygous
    Cx3cr1_homozygous
    Cx3cr1_WT
    Cx3cr1-GFP_heterozygous
    Cx3cr1-GFP_homozygous
    Cx3cr1-GFP_WT
    D2Mit367-D2_heterozygous
    D2Mit367-D2_homozygous
    D2Mit367-D2_WT
    d4MIT251-D2_heterozygous
    d4MIT251-D2_homozygous
    d4MIT251-D2_WT
    Dlx6a-Cre_heterozygous
    Dlx6a-Cre_homozygous
    Dlx6a-Cre_WT
    Edn2-FLX_heterozygous
    Edn2-FLX_homozygous
    Edn2-FLX_WT
    Edn2-KO_heterozygous
    Edn2-KO_homozygous
    Edn2-KO_WT
    Emx1-Cre_heterozygous
    Emx1-Cre_homozygous
    Emx1-Cre_WT
    Epha1 -P460L_heterozygous
    Epha1 -P460L_homozygous
    Epha1 -P460L_WT
    Epha1-KI_heterozygous
    Epha1-KI_homozygous
    Epha1-KI_WT
    Epha1-KO_heterozygous
    Epha1-KO_homozygous
    Epha1-KO_WT
    Erc2-KI_heterozygous
    Erc2-KI_homozygous
    Erc2-KI_WT
    Erc2-KO_heterozygous
    Erc2-KO_homozygous
    Erc2-KO_WT
    Gad2-Cre_heterozygous
    Gad2-Cre_homozygous
    Gad2-Cre_WT
    Gamma_heterozygous
    Gamma_homozygous
    Gamma_WT
    Gpnmb_heterozygous
    Gpnmb_homozygous
    Gpnmb_WT
    Gpnmb-pyro_heterozygous
    Gpnmb-pyro_homozygous
    Gpnmb-pyro_WT
    Gpnmb-SEQ_heterozygous
    Gpnmb-SEQ_homozygous
    Gpnmb-SEQ_WT
    hAbeta-KI_LoxP_heterozygous
    hAbeta-KI_LoxP_homozygous
    hAbeta-KI_LoxP_WT
    hAPP-3/3_heterozygous
    hAPP-3/3_homozygous
    hAPP-3/3_WT
    hAPP-Arc_heterozygous
    hAPP-Arc_homozygous
    hAPP-Arc_WT
    hAPP-Aus_heterozygous
    hAPP-Aus_homozygous
    hAPP-Aus_WT
    hAPP-KO_heterozygous
    hAPP-KO_homozygous
    hAPP-KO_WT
    hAPP-SFL_heterozygous
    hAPP-SFL_homozygous
    hAPP-SFL_WT
    hAPP-Swe_heterozygous
    hAPP-Swe_homozygous
    hAPP-Swe_WT
    hTau-H1_heterozygous
    hTau-H1_homozygous
    hTau-H1_WT
    hTau-H2_heterozygous
    hTau-H2_homozygous
    hTau-H2_WT
    I134-KO_heterozygous
    I134-KO_homozygous
    I134-KO_WT
    IL1rapb-cKO_heterozygous
    IL1rapb-cKO_homozygous
    IL1rapb-cKO_WT
    IL1RAPex2-KO_heterozygous
    IL1RAPex2-KO_homozygous
    IL1RAPex2-KO_WT
    IL1RAPex3-KO_heterozygous
    IL1RAPex3-KO_homozygous
    IL1RAPex3-KO_WT
    J20_carrier
    J20_noncarrier
    Kif21b-KI_heterozygous
    Kif21b-KI_homozygous
    Kif21b-KI_WT
    Kif21b-KO_heterozygous
    Kif21b-KO_homozygous
    Kif21b-KO_WT
    Lyz2_heterozygous
    Lyz2_homozygous
    Lyz2_WT
    mApoe_heterozygous
    mApoe_homozygous
    mApoe_WT
    mApoe-KO_heterozygous
    mApoe-KO_homozygous
    mApoe-KO_WT
    Meox2-Cre_heterozygous
    Meox2-Cre_homozygous
    Meox2-Cre_WT
    mTau_heterozygous
    mTau_homozygous
    mTau_WT
    mTau-KO_heterozygous
    mTau-KO_homozygous
    mTau-KO_WT
    Mthfr-KI_heterozygous
    Mthfr-KI_homozygous
    Mthfr-KI_WT
    Mthfr-KO_heterozygous
    Mthfr-KO_homozygous
    Mthfr-KO_WT
    Mtmr4-KI_heterozygous
    Mtmr4-KI_homozygous
    Mtmr4-KI_WT
    Mtmr4-KO_heterozygous
    Mtmr4-KO_homozygous
    Mtmr4-KO_WT
    mTrem2-KO_heterozygous
    mTrem2-KO_homozygous
    mTrem2-KO_WT
    Nes_heterozygous
    Nes_homozygous
    Nes_WT
    NPC_heterozygous
    NPC_homozygous
    NPC_WT
    Picalm-H458R_heterozygous
    Picalm-H458R_homozygous
    Picalm-H458R_WT
    Plcg2-KI_heterozygous
    Plcg2-KI_homozygous
    Plcg2-KI_WT
    Plcg2-KO_heterozygous
    Plcg2-KO_homozygous
    Plcg2-KO_WT
    Plp1_heterozygous
    Plp1_homozygous
    Plp1_WT
    Psen1-3xTG_carrier
    Psen1-3xTG_noncarrier
    PSEN1-KI_heterozygous
    PSEN1-KI_homozygous
    PSEN1-KI_WT
    PSEN1dE9_carrier
    PSEN1dE9_noncarrier
    Ptprb-KI_heterozygous
    Ptprb-KI_homozygous
    Ptprb-KI_WT
    Shc2-KI_heterozygous
    Shc2-KI_homozygous
    Shc2-KI_WT
    Shc2-KO_heterozygous
    Shc2-KO_homozygous
    Shc2-KO_WT
    Snx1-KI_heterozygous
    Snx1-KI_homozygous
    Snx1-KI_WT
    Sorl1-KI_heterozygous
    Sorl1-KI_homozygous
    Sorl1-KI_WT
    Sorl1-KO_heterozygous
    Sorl1-KO_homozygous
    Sorl1-KO_WT
    Sox2-Cre_heterozygous
    Sox2-Cre_homozygous
    Sox2-Cre_WT
    Spi1-rs1377416_heterozygous
    Spi1-rs1377416_homozygous
    Spi1-rs1377416_WT
    Stat3-FLX_heterozygous
    Stat3-FLX_homozygous
    Stat3-FLX_WT
    Stat3-KO_heterozygous
    Stat3-KO_homozygous
    Stat3-KO_WT
    Thy1_heterozygous
    Thy1_homozygous
    Thy1_WT
    Tie2-GFP_heterozygous
    Tie2-GFP_homozygous
    Tie2-GFP_WT
    TM1A_carrier
    TM1A_noncarrier
    TM1C_carrier
    TM1C_noncarrier
    TM1D_carrier
    TM1D_noncarrier
    TMEM119_heterozygous
    TMEM119_homozygous
    TMEM119_WT
    Trem2-R47H_heterozygous
    Trem2-R47H_homozygous
    Trem2-R47H_NSS_heterozygous
    Trem2-R47H_NSS_homozygous
    Trem2-R47H_NSS_WT
    Trem2-R47H_WT
    XFP_heterozygous
    XFP_homozygous
    XFP_WT

    genotypeBackground

    Genetic background of the model

    Expand
    titleMODEL-AD-approved Values

    C57BL6J
    C57BL6N
    CC037
    CC041
    CC013
    CC006
    CC002
    CC017
    B6JCC037
    B6JCC041
    B6JCC013
    B6JCC006
    B6JCC002
    B6JCC017
    LOAD1
    LOAD2

    Expand
    titleValues with JAX stockNumbers of background strains

    C57BL6J (000664) C57BL6N (005304)
    C57BL6J:C57BL6N (#000664 & #005304)

    CC037 (#025423)

    CC041 (#021893)

    CC013 (#021892)

    CC006 (#022869)

    CC002 (#021236)

    CC017 (#022870)

    B6JCC037(#000664 & #025423)

    B6JCC041(#000664 & #021893)

    B6JCC013(#000664 & #021892)

    B6JCC006(#000664 & #022869)

    B6JCC002(#000664 & #021236)

    B6JCC017(#000664 & #02870)
    LOAD1

    --

    (

    #028709

    028709)
    LOAD2

    --

    (

    #030670

    030670)

    individualCommonGenotype

    Genotype of animal with LOADterminology (used by MODEL-AD Explorer)-terminology

    LOAD1:

    • APOE4_homozygous

    • TREM2R47H_homozygous

    LOAD2:

    • APOE4_homozygous

    • TREM2R47H_homozygous

    • ABETA_homozygous

    • LOAD1:

      • APOE4_homozygous

      • TREM2R47H_homozygous

    • LOAD2:

      • APOE4_homozygous

      • TREM2R47H_homozygous

      • ABETA_homozygous

    • C57BL6J

    • 5XFAD

    • APOE4

    • Trem2R47H

    Expand
    titleControlled Values

    LOAD1
    LOAD2
    LOAD1.ABCA7A1527G
    LOAD1.CEACAM1KO
    LOAD1.

    CR1long

    Clasp2L163P
    LOAD1.

    Clasp2L163P

    CR1long
    LOAD1.Il1rapExon2KO
    LOAD1.MthfrC677T
    LOAD1.Plcg2M28L
    LOAD1.Snx1D465N
    Trem2R47H
    C57BL6J
    5XFAD
    APOE4

    officialName

    Official JAX Mice strain nomenclature.

    Full name indicating all transgenes.

    https://mice.jax.org

    • C57BL/6J

    • B6(SJL)-Apoetm1Apoetm1.1(APOE*4)Adiuj Trem2em1AdiujAdiuj Trem2em1Adiuj/J

    modelSystemName

    Strain annotation - see AMP-AD Metadata Dictionary. Used as file annotation

    Abca7A1527GAPOE4Trem2R47H

    See data query

    Values: https://www.synapse.org/#!Synapse:syn10242922/tables/query/eyJzcWwiOiJTRUxFQ1QgRElTVElOQ1QgIHZhbHVlIEZST00gc3luMTAyNDI5MjIgV0hFUkUgKCggXCJrZXlcIiA9ICdtb2RlbFN5c3RlbU5hbWUnICkgKSIsICJhZGRpdGlvbmFsRmlsdGVycyI6W10sICJpbmNsdWRlRW50aXR5RXRhZyI6dHJ1ZSwgIm9mZnNldCI6MCwgImxpbWl0IjoyNSwgInNvcnQiOltdfQ==

    Example: 3xTg-AD

    stockNumber

    The JAX stock number 030283(6-digit)

    Example: 000664