Genotypes
These are the variables describing describe the mice in the Individual Metadata file. The modelSystemName is used as file annotation. The AD Model Explorer uses the LOAD definition.
Example | officialName | Full name indicating all transgenes, taken from the strain’s Jax datasheet | B6.Cg-Apoetm1.1(APOE*4)Adiuj Abca7em2Adiuj Trem2em1Adiuj/J |
modelSystemName | Strain annotation - see AMP-AD Metadata Dictionary. Used as file annotation | Abca7A1527GAPOE4Trem2R47H See data query |
stockNumber | The Jax stock number | 030283 |
genotypeBackground | Background genotype | C57BL6J |
genotype | Genotype of animal that indicates littermate carriers vs noncarriers | APOE4_homozygous; TREM2R47H_homozygous; ABCA7KI_NONCARRIER APOE4_homozygous; TREM2R47H_homozygous; ABCA7KI_HOMOZYGOUS |
individualCommonGenotype | Genotype of animal that includes LOAD1 or LOAD2 terminology. This is the model name used in the AD Model Explorer LOAD1= APOE4_HOMOZYGOUS; TREM2R47H_HOMOZYGOUS. LOAD2=APOE4_HOMOZYGOUS; TREM2R47H_HOMOZYGOUS; ABETA_HOMOZYGOUS | LOAD1
LOAD1.ABCA7A1527Value |
genotype
| Genotype of animal that indicates littermate carriers vs noncarriers. Names derived from joining three Climb variables in this specific format: gene-allele_genotype
| | Expand |
|---|
| title | MODEL-AD-approved Values |
|---|
| 3xTg-AD_carrier
3xTg-AD_noncarrier
5XFAD_carrier
5XFAD_noncarrier
Abca7-KI_heterozygous
Abca7-KI_homozygous
Abca7-KI_WT
Abca7-KO_heterozygous
Abca7-KO_homozygous
Abca7-KO_WT
Abca7-V1599M_heterozygous
Abca7-V1599M_homozygous
Abca7-V1599M_WT
Abi3-S209F_heterozygous
Abi3-S209F_homozygous
Abi3-S209F_WT
APOE2-KI_heterozygous
APOE2-KI_homozygous
APOE2-KI_WT
APOE3-KI_heterozygous
APOE3-KI_homozygous
APOE3-KI_WT
APOE4-KI_heterozygous
APOE4-KI_homozygous
APOE4-KI_WT
APP 3&5_carrier
APP 3&5_noncarrier
APPswe_carrier
APPswe_noncarrier
B2M-KO_heterozygous
B2M-KO_homozygous
B2M-KO_WT
Bin1-FLX_heterozygous
Bin1-FLX_homozygous
Bin1-FLX_WT
Bin1-K358R_heterozygous
Bin1-K358R_homozygous
Bin1-K358R_WT
Bin1-KI_heterozygous
Bin1-KI_homozygous
Bin1-KI_WT
Bin1-KO_heterozygous
Bin1-KO_homozygous
Bin1-KO_WT
C3-KO_heterozygous
C3-KO_homozygous
C3-KO_WT
C5-D2_heterozygous
C5-D2_homozygous
C5-D2_WT
C5-KO_heterozygous
C5-KO_homozygous
C5-KO_WT
Cd2ap-KI_heterozygous
Cd2ap-KI_homozygous
Cd2ap-KI_WT
Cd2ap-KO_heterozygous
Cd2ap-KO_homozygous
Cd2ap-KO_WT
Ceacam1-KO_heterozygous
Ceacam1-KO_homozygous
Ceacam1-KO_WT
Clasp2-KI_heterozygous
Clasp2-KI_homozygous
Clasp2-KI_WT
Clasp2-KO_heterozygous
Clasp2-KO_homozygous
Clasp2-KO_WT
Clu-KO_heterozygous
Clu-KO_homozygous
Clu-KO_WT
Clu-rs2279590_KI_heterozygous
Clu-rs2279590_KI_homozygous
Clu-rs2279590_KI_WT
Clu-rs9331888_heterozygous
Clu-rs9331888_homozygous
Clu-rs9331888_WT
Clu-rs9331888nr_heterozygous
Clu-rs9331888nr_homozygous
Clu-rs9331888nr_WT
CR1-KO_heterozygous
CR1-KO_homozygous
CR1-KO_WT
CR1-long_heterozygous
CR1-long_homozygous
CR1-long_WT
CR1-short_heterozygous
CR1-short_homozygous
CR1-short_WT
CR2CR1_heterozygous
CR2CR1_homozygous
CR2CR1_WT
Cx3cr1_heterozygous
Cx3cr1_homozygous
Cx3cr1_WT
Cx3cr1-GFP_heterozygous
Cx3cr1-GFP_homozygous
Cx3cr1-GFP_WT
D2Mit367-D2_heterozygous
D2Mit367-D2_homozygous
D2Mit367-D2_WT
d4MIT251-D2_heterozygous
d4MIT251-D2_homozygous
d4MIT251-D2_WT
Dlx6a-Cre_heterozygous
Dlx6a-Cre_homozygous
Dlx6a-Cre_WT
Edn2-FLX_heterozygous
Edn2-FLX_homozygous
Edn2-FLX_WT
Edn2-KO_heterozygous
Edn2-KO_homozygous
Edn2-KO_WT
Emx1-Cre_heterozygous
Emx1-Cre_homozygous
Emx1-Cre_WT
Epha1 -P460L_heterozygous
Epha1 -P460L_homozygous
Epha1 -P460L_WT
Epha1-KI_heterozygous
Epha1-KI_homozygous
Epha1-KI_WT
Epha1-KO_heterozygous
Epha1-KO_homozygous
Epha1-KO_WT
Erc2-KI_heterozygous
Erc2-KI_homozygous
Erc2-KI_WT
Erc2-KO_heterozygous
Erc2-KO_homozygous
Erc2-KO_WT
Gad2-Cre_heterozygous
Gad2-Cre_homozygous
Gad2-Cre_WT
Gamma_heterozygous
Gamma_homozygous
Gamma_WT
Gpnmb_heterozygous
Gpnmb_homozygous
Gpnmb_WT
Gpnmb-pyro_heterozygous
Gpnmb-pyro_homozygous
Gpnmb-pyro_WT
Gpnmb-SEQ_heterozygous
Gpnmb-SEQ_homozygous
Gpnmb-SEQ_WT
hAbeta-KI_LoxP_heterozygous
hAbeta-KI_LoxP_homozygous
hAbeta-KI_LoxP_WT
hAPP-3/3_heterozygous
hAPP-3/3_homozygous
hAPP-3/3_WT
hAPP-Arc_heterozygous
hAPP-Arc_homozygous
hAPP-Arc_WT
hAPP-Aus_heterozygous
hAPP-Aus_homozygous
hAPP-Aus_WT
hAPP-KO_heterozygous
hAPP-KO_homozygous
hAPP-KO_WT
hAPP-SFL_heterozygous
hAPP-SFL_homozygous
hAPP-SFL_WT
hAPP-Swe_heterozygous
hAPP-Swe_homozygous
hAPP-Swe_WT
hTau-H1_heterozygous
hTau-H1_homozygous
hTau-H1_WT
hTau-H2_heterozygous
hTau-H2_homozygous
hTau-H2_WT
I134-KO_heterozygous
I134-KO_homozygous
I134-KO_WT
IL1rapb-cKO_heterozygous
IL1rapb-cKO_homozygous
IL1rapb-cKO_WT
IL1RAPex2-KO_heterozygous
IL1RAPex2-KO_homozygous
IL1RAPex2-KO_WT
IL1RAPex3-KO_heterozygous
IL1RAPex3-KO_homozygous
IL1RAPex3-KO_WT
J20_carrier
J20_noncarrier
Kif21b-KI_heterozygous
Kif21b-KI_homozygous
Kif21b-KI_WT
Kif21b-KO_heterozygous
Kif21b-KO_homozygous
Kif21b-KO_WT
Lyz2_heterozygous
Lyz2_homozygous
Lyz2_WT
mApoe_heterozygous
mApoe_homozygous
mApoe_WT
mApoe-KO_heterozygous
mApoe-KO_homozygous
mApoe-KO_WT
Meox2-Cre_heterozygous
Meox2-Cre_homozygous
Meox2-Cre_WT
mTau_heterozygous
mTau_homozygous
mTau_WT
mTau-KO_heterozygous
mTau-KO_homozygous
mTau-KO_WT
Mthfr-KI_heterozygous
Mthfr-KI_homozygous
Mthfr-KI_WT
Mthfr-KO_heterozygous
Mthfr-KO_homozygous
Mthfr-KO_WT
Mtmr4-KI_heterozygous
Mtmr4-KI_homozygous
Mtmr4-KI_WT
Mtmr4-KO_heterozygous
Mtmr4-KO_homozygous
Mtmr4-KO_WT
mTrem2-KO_heterozygous
mTrem2-KO_homozygous
mTrem2-KO_WT
Nes_heterozygous
Nes_homozygous
Nes_WT
NPC_heterozygous
NPC_homozygous
NPC_WT
Picalm-H458R_heterozygous
Picalm-H458R_homozygous
Picalm-H458R_WT
Plcg2-KI_heterozygous
Plcg2-KI_homozygous
Plcg2-KI_WT
Plcg2-KO_heterozygous
Plcg2-KO_homozygous
Plcg2-KO_WT
Plp1_heterozygous
Plp1_homozygous
Plp1_WT
Psen1-3xTG_carrier
Psen1-3xTG_noncarrier
PSEN1-KI_heterozygous
PSEN1-KI_homozygous
PSEN1-KI_WT
PSEN1dE9_carrier
PSEN1dE9_noncarrier
Ptprb-KI_heterozygous
Ptprb-KI_homozygous
Ptprb-KI_WT
Shc2-KI_heterozygous
Shc2-KI_homozygous
Shc2-KI_WT
Shc2-KO_heterozygous
Shc2-KO_homozygous
Shc2-KO_WT
Snx1-KI_heterozygous
Snx1-KI_homozygous
Snx1-KI_WT
Sorl1-KI_heterozygous
Sorl1-KI_homozygous
Sorl1-KI_WT
Sorl1-KO_heterozygous
Sorl1-KO_homozygous
Sorl1-KO_WT
Sox2-Cre_heterozygous
Sox2-Cre_homozygous
Sox2-Cre_WT
Spi1-rs1377416_heterozygous
Spi1-rs1377416_homozygous
Spi1-rs1377416_WT
Stat3-FLX_heterozygous
Stat3-FLX_homozygous
Stat3-FLX_WT
Stat3-KO_heterozygous
Stat3-KO_homozygous
Stat3-KO_WT
Thy1_heterozygous
Thy1_homozygous
Thy1_WT
Tie2-GFP_heterozygous
Tie2-GFP_homozygous
Tie2-GFP_WT
TM1A_carrier
TM1A_noncarrier
TM1C_carrier
TM1C_noncarrier
TM1D_carrier
TM1D_noncarrier
TMEM119_heterozygous
TMEM119_homozygous
TMEM119_WT
Trem2-R47H_heterozygous
Trem2-R47H_homozygous
Trem2-R47H_NSS_heterozygous
Trem2-R47H_NSS_homozygous
Trem2-R47H_NSS_WT
Trem2-R47H_WT
XFP_heterozygous
XFP_homozygous
XFP_WT
|
|
genotypeBackground
| Genetic background of the model | | Expand |
|---|
| title | MODEL-AD-approved Values |
|---|
| C57BL6J
C57BL6N
CC037
CC041
CC013
CC006
CC002
CC017
B6JCC037
B6JCC041
B6JCC013
B6JCC006
B6JCC002
B6JCC017
LOAD1
LOAD2
|
| Expand |
|---|
| title | Values with JAX stockNumbers of background strains |
|---|
| C57BL6J (000664) C57BL6N (005304)
C57BL6J:C57BL6N (#000664 & #005304) CC037 (#025423) CC041 (#021893) CC013 (#021892) CC006 (#022869) CC002 (#021236) CC017 (#022870) B6JCC037(#000664 & #025423) B6JCC041(#000664 & #021893) B6JCC013(#000664 & #021892) B6JCC006(#000664 & #022869) B6JCC002(#000664 & #021236) B6JCC017(#000664 & #02870)
LOAD1 (028709)
LOAD2 (030670)
|
|
individualCommonGenotype
| Genotype of animal with LOAD-terminology LOAD1: APOE4_homozygous TREM2R47H_homozygous
LOAD2: APOE4_homozygous TREM2R47H_homozygous ABETA_homozygous
| | Expand |
|---|
| LOAD1
LOAD2
LOAD1.ABCA7A1527G
LOAD1.CEACAM1KO
LOAD1.Clasp2L163P
LOAD1.CR1long
LOAD1.Il1rapExon2KO
LOAD1.MthfrC677T
LOAD1.Plcg2M28L
LOAD1.Snx1D465N
Trem2R47H
C57BL6J
5XFAD
APOE4
|
|
officialName
| Official JAX Mice strain nomenclature. Full name indicating all transgenes. https://mice.jax.org | |
modelSystemName
| Strain annotation | Values: https://www.synapse.org/#!Synapse:syn10242922/tables/query/eyJzcWwiOiJTRUxFQ1QgRElTVElOQ1QgIHZhbHVlIEZST00gc3luMTAyNDI5MjIgV0hFUkUgKCggXCJrZXlcIiA9ICdtb2RlbFN5c3RlbU5hbWUnICkgKSIsICJhZGRpdGlvbmFsRmlsdGVycyI6W10sICJpbmNsdWRlRW50aXR5RXRhZyI6dHJ1ZSwgIm9mZnNldCI6MCwgImxpbWl0IjoyNSwgInNvcnQiOltdfQ== Example: 3xTg-AD |
stockNumber
| The JAX stock number (6-digit) | Example: 000664 |
