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Variable

Definition

Value

genotype

Genotype of animal that indicates littermate carriers vs noncarriers.

  • Naming Format format derived from Climb variables:<gene>-<allele>_<genotype_symbol>

  • See complete list of acceptable values:

    Lref gdrive file
    urlhttps://docs.google.com/spreadsheets/d/1vRJ0SKHHaj61LpJ54nQQUyRWhuGFWgPcmbPuAAj4gZk/edit?usp=sharing

  • Genes

    • 5XFAD (transgene)

    • 3xTg (transgene)

    • APOE4

    • hAbeta

    • Trem2

    • Picalm

    • Bin1

    • Abca7

    • Spi1

    • Abi3

    • Clu

    • Epha1

  • Allele

    • KI

    • KO

    • FLX

    • Cre

    • 3xTg

    • R47h

    • GFP

    • Arc

    • Swe

    • Aus

    • Lon

    • Flo

    • Tg

    • KI_LoxP

    • M146V

    • R47H_NSS

    • H458R

    • K358R

    • V1599M

    • rs9331888nr

    • rs9331888

    • rs1377614

    • rs2279590_KI

    • S209F

    • rs243559662

    • P460L

  • Genotype Symbols

  • WT

  • heterozygous

  • homozygous

  • carrier (transgenes only)

  • noncarrier (transgenes only)

    joining three Climb variables:gene-allele_genotype

Expand
titleList of Controlled Values

3xTg-AD_carrier
3xTg-AD_noncarrier
5XFAD_carrier
5XFAD_noncarrier
Abca7-KI_heterozygous
Abca7-KI_homozygous
Abca7-KI_WT
Abca7-KO_heterozygous
Abca7-KO_homozygous
Abca7-KO_WT
Abca7-V1599M_heterozygous
Abca7-V1599M_homozygous
Abca7-V1599M_WT
Abi3-S209F_heterozygous
Abi3-S209F_homozygous
Abi3-S209F_WT
APOE2-KI_heterozygous
APOE2-KI_homozygous
APOE2-KI_WT
APOE3-KI_heterozygous
APOE3-KI_homozygous
APOE3-KI_WT
APOE4-KI_heterozygous
APOE4-KI_homozygous
APOE4-KI_WT
APP 3&5_carrier
APP 3&5_noncarrier
APPswe_carrier
APPswe_noncarrier
B2M-KO_heterozygous
B2M-KO_homozygous
B2M-KO_WT
Bin1-FLX_heterozygous
Bin1-FLX_homozygous
Bin1-FLX_WT
Bin1-K358R_heterozygous
Bin1-K358R_homozygous
Bin1-K358R_WT
Bin1-KI_heterozygous
Bin1-KI_homozygous
Bin1-KI_WT
Bin1-KO_heterozygous
Bin1-KO_homozygous
Bin1-KO_WT
C3-KO_heterozygous
C3-KO_homozygous
C3-KO_WT
C5-D2_heterozygous
C5-D2_homozygous
C5-D2_WT
C5-KO_heterozygous
C5-KO_homozygous
C5-KO_WT
Cd2ap-KI_heterozygous
Cd2ap-KI_homozygous
Cd2ap-KI_WT
Cd2ap-KO_heterozygous
Cd2ap-KO_homozygous
Cd2ap-KO_WT
Ceacam1-KO_heterozygous
Ceacam1-KO_homozygous
Ceacam1-KO_WT
Clasp2-KI_heterozygous
Clasp2-KI_homozygous
Clasp2-KI_WT
Clasp2-KO_heterozygous
Clasp2-KO_homozygous
Clasp2-KO_WT
Clu-KO_heterozygous
Clu-KO_homozygous
Clu-KO_WT
Clu-rs2279590_KI_heterozygous
Clu-rs2279590_KI_homozygous
Clu-rs2279590_KI_WT
Clu-rs9331888_heterozygous
Clu-rs9331888_homozygous
Clu-rs9331888_WT
Clu-rs9331888nr_heterozygous
Clu-rs9331888nr_homozygous
Clu-rs9331888nr_WT
CR1-KO_heterozygous
CR1-KO_homozygous
CR1-KO_WT
CR1-long_heterozygous
CR1-long_homozygous
CR1-long_WT
CR1-short_heterozygous
CR1-short_homozygous
CR1-short_WT
CR2CR1_heterozygous
CR2CR1_homozygous
CR2CR1_WT
Cx3cr1_heterozygous
Cx3cr1_homozygous
Cx3cr1_WT
Cx3cr1-GFP_heterozygous
Cx3cr1-GFP_homozygous
Cx3cr1-GFP_WT
D2Mit367-D2_heterozygous
D2Mit367-D2_homozygous
D2Mit367-D2_WT
d4MIT251-D2_heterozygous
d4MIT251-D2_homozygous
d4MIT251-D2_WT
Dlx6a-Cre_heterozygous
Dlx6a-Cre_homozygous
Dlx6a-Cre_WT
Edn2-FLX_heterozygous
Edn2-FLX_homozygous
Edn2-FLX_WT
Edn2-KO_heterozygous
Edn2-KO_homozygous
Edn2-KO_WT
Emx1-Cre_heterozygous
Emx1-Cre_homozygous
Emx1-Cre_WT
Epha1 -P460L_heterozygous
Epha1 -P460L_homozygous
Epha1 -P460L_WT
Epha1-KI_heterozygous
Epha1-KI_homozygous
Epha1-KI_WT
Epha1-KO_heterozygous
Epha1-KO_homozygous
Epha1-KO_WT
Erc2-KI_heterozygous
Erc2-KI_homozygous
Erc2-KI_WT
Erc2-KO_heterozygous
Erc2-KO_homozygous
Erc2-KO_WT
Gad2-Cre_heterozygous
Gad2-Cre_homozygous
Gad2-Cre_WT
Gamma_heterozygous
Gamma_homozygous
Gamma_WT
Gpnmb_heterozygous
Gpnmb_homozygous
Gpnmb_WT
Gpnmb-pyro_heterozygous
Gpnmb-pyro_homozygous
Gpnmb-pyro_WT
Gpnmb-SEQ_heterozygous
Gpnmb-SEQ_homozygous
Gpnmb-SEQ_WT
hAbeta-KI_LoxP_heterozygous
hAbeta-KI_LoxP_homozygous
hAbeta-KI_LoxP_WT
hAPP-3/3_heterozygous
hAPP-3/3_homozygous
hAPP-3/3_WT
hAPP-Arc_heterozygous
hAPP-Arc_homozygous
hAPP-Arc_WT
hAPP-Aus_heterozygous
hAPP-Aus_homozygous
hAPP-Aus_WT
hAPP-KO_heterozygous
hAPP-KO_homozygous
hAPP-KO_WT
hAPP-SFL_heterozygous
hAPP-SFL_homozygous
hAPP-SFL_WT
hAPP-Swe_heterozygous
hAPP-Swe_homozygous
hAPP-Swe_WT
hTau-H1_heterozygous
hTau-H1_homozygous
hTau-H1_WT
hTau-H2_heterozygous
hTau-H2_homozygous
hTau-H2_WT
I134-KO_heterozygous
I134-KO_homozygous
I134-KO_WT
IL1rapb-cKO_heterozygous
IL1rapb-cKO_homozygous
IL1rapb-cKO_WT
IL1RAPex2-KO_heterozygous
IL1RAPex2-KO_homozygous
IL1RAPex2-KO_WT
IL1RAPex3-KO_heterozygous
IL1RAPex3-KO_homozygous
IL1RAPex3-KO_WT
J20_carrier
J20_noncarrier
Kif21b-KI_heterozygous
Kif21b-KI_homozygous
Kif21b-KI_WT
Kif21b-KO_heterozygous
Kif21b-KO_homozygous
Kif21b-KO_WT
Lyz2_heterozygous
Lyz2_homozygous
Lyz2_WT
mApoe_heterozygous
mApoe_homozygous
mApoe_WT
mApoe-KO_heterozygous
mApoe-KO_homozygous
mApoe-KO_WT
Meox2-Cre_heterozygous
Meox2-Cre_homozygous
Meox2-Cre_WT
mTau_heterozygous
mTau_homozygous
mTau_WT
mTau-KO_heterozygous
mTau-KO_homozygous
mTau-KO_WT
Mthfr-KI_heterozygous
Mthfr-KI_homozygous
Mthfr-KI_WT
Mthfr-KO_heterozygous
Mthfr-KO_homozygous
Mthfr-KO_WT
Mtmr4-KI_heterozygous
Mtmr4-KI_homozygous
Mtmr4-KI_WT
Mtmr4-KO_heterozygous
Mtmr4-KO_homozygous
Mtmr4-KO_WT
mTrem2-KO_heterozygous
mTrem2-KO_homozygous
mTrem2-KO_WT
Nes_heterozygous
Nes_homozygous
Nes_WT
NPC_heterozygous
NPC_homozygous
NPC_WT
Picalm-H458R_heterozygous
Picalm-H458R_homozygous
Picalm-H458R_WT
Plcg2-KI_heterozygous
Plcg2-KI_homozygous
Plcg2-KI_WT
Plcg2-KO_heterozygous
Plcg2-KO_homozygous
Plcg2-KO_WT
Plp1_heterozygous
Plp1_homozygous
Plp1_WT
Psen1-3xTG_carrier
Psen1-3xTG_noncarrier
PSEN1-KI_heterozygous
PSEN1-KI_homozygous
PSEN1-KI_WT
PSEN1dE9_carrier
PSEN1dE9_noncarrier
Ptprb-KI_heterozygous
Ptprb-KI_homozygous
Ptprb-KI_WT
Shc2-KI_heterozygous
Shc2-KI_homozygous
Shc2-KI_WT
Shc2-KO_heterozygous
Shc2-KO_homozygous
Shc2-KO_WT
Snx1-KI_heterozygous
Snx1-KI_homozygous
Snx1-KI_WT
Sorl1-KI_heterozygous
Sorl1-KI_homozygous
Sorl1-KI_WT
Sorl1-KO_heterozygous
Sorl1-KO_homozygous
Sorl1-KO_WT
Sox2-Cre_heterozygous
Sox2-Cre_homozygous
Sox2-Cre_WT
Spi1-rs1377416_heterozygous
Spi1-rs1377416_homozygous
Spi1-rs1377416_WT
Stat3-FLX_heterozygous
Stat3-FLX_homozygous
Stat3-FLX_WT
Stat3-KO_heterozygous
Stat3-KO_homozygous
Stat3-KO_WT
Thy1_heterozygous
Thy1_homozygous
Thy1_WT
Tie2-GFP_heterozygous
Tie2-GFP_homozygous
Tie2-GFP_WT
TM1A_carrier
TM1A_noncarrier
TM1C_carrier
TM1C_noncarrier
TM1D_carrier
TM1D_noncarrier
TMEM119_heterozygous
TMEM119_homozygous
TMEM119_WT
Trem2-R47H_heterozygous
Trem2-R47H_homozygous
Trem2-R47H_NSS_heterozygous
Trem2-R47H_NSS_homozygous
Trem2-R47H_NSS_WT
Trem2-R47H_WT
XFP_heterozygous
XFP_homozygous
XFP_WT

genotypeBackground

Genetic background of the model

  • C57BL6J (#000664, JAX link)

  • C57BL6N (#005304)

  • C57BL6J:C57BL6N (#000664 & #005304)

  • CC037 (#025423)

  • CC041 (#021893)

  • CC013 (#021892)

  • CC006 (#022869)

  • CC002 (#021236)

  • CC017 (#022870)

  • B6JCC037(#000664 & #025423)

  • B6JCC041(#000664 & #021893)

  • B6JCC013(#000664 & #021892)

  • B6JCC006(#000664 & #022869)

  • B6JCC002(#000664 & #021236)

  • B6JCC017(#000664 & #02870)

  • LOAD1--(#028709)

  • LOAD2--(#030670)

individualCommonGenotype

Genotype of animal with LOADterminology (used by MODEL-AD Explorer)-terminology

LOAD1:

  • APOE4_homozygous

  • TREM2R47H_homozygous

LOAD2:

  • APOE4_homozygous

  • TREM2R47H_homozygous

  • ABETA_homozygous

  • LOAD1:

    • APOE4_homozygous

    • TREM2R47H_homozygous

  • LOAD2 :

    • APOE4_homozygous

    • TREM2R47H_homozygous

    • ABETA_homozygous

  • C57BL6J

  • 5XFAD

  • APOE4

  • Trem2R47H

  • LOAD1.ABCA7A1527G

  • LOAD1.CEACAM1KO

  • LOAD1.CR1long

  • LOAD1.Clasp2L163P

  • LOAD1.Il1rapExon2KO

  • LOAD1.MthfrC677T

  • LOAD1.Plcg2M28L

  • LOAD1.Snx1D465N

officialName

Official JAX Mice strain nomenclature.

Full name indicating all transgenes.

https://mice.jax.org

  • C57BL/6J

  • B6(SJL)-Apoetm1Apoetm1.1(APOE*4)Adiuj Trem2em1AdiujAdiuj Trem2em1Adiuj/J

modelSystemName

Strain annotation - see AMP-AD Metadata Dictionary. Used as file annotation

Abca7A1527GAPOE4Trem2R47H

See data query

Values: https://www.synapse.org/#!Synapse:syn10242922/tables/query/eyJzcWwiOiJTRUxFQ1QgRElTVElOQ1QgIHZhbHVlIEZST00gc3luMTAyNDI5MjIgV0hFUkUgKCggXCJrZXlcIiA9ICdtb2RlbFN5c3RlbU5hbWUnICkgKSIsICJhZGRpdGlvbmFsRmlsdGVycyI6W10sICJpbmNsdWRlRW50aXR5RXRhZyI6dHJ1ZSwgIm9mZnNldCI6MCwgImxpbWl0IjoyNSwgInNvcnQiOltdfQ==

Example: 3xTg-AD

stockNumber

The JAX stock number (6-digit)

Example: 030283