Page Comparison

Variable

Definition

Value

genotype

Genotype of animal that indicates littermate carriers vs noncarriers.

• Naming Format

• from Climb variables:<gene>-<allele>_<genotype_symbol>

• See complete list of

• acceptable values:

• APOE4-KI_heterozygous

• APOE4-KI_homozygous

• APOE4-KI_WT

• 3xTg-AD_carrier

• 3xTg-AD_noncarrier

officialName

Full name indicating all transgenes, taken from the strain’s JAX datasheet

• B6.Cg-Apoetm1.1(APOE*4)Adiuj

• Abca7em2Adiuj Trem2em1Adiuj/J

modelSystemName

Strain annotation - see AMP-AD Metadata Dictionary. Used as file annotation

Abca7A1527GAPOE4Trem2R47H

See data query

• Lref gdrive file
  url https://docs.google.com/spreadsheets/d/1vRJ0SKHHaj61LpJ54nQQUyRWhuGFWgPcmbPuAAj4gZk/edit?usp=sharing

• Genes

  • 5XFAD (transgene)

  • 3xTg (transgene)

  • APOE4

  • hAbeta

  • Trem2

  • Picalm

  • Bin1

  • Abca7

  • Spi1

  • Abi3

  • Clu

  • Epha1

• Allele

  • KI

  • KO

  • FLX

  • Cre

  • 3xTg

  • R47h

  • GFP

  • Arc

  • Swe

  • Aus

  • Lon

  • Flo

  • Tg

  • KI_LoxP

  • M146V

  • R47H_NSS

  • H458R

  • K358R

  • V1599M

  • rs9331888nr

  • rs9331888

  • rs1377614

  • rs2279590_KI

  • S209F

  • rs243559662

  • P460L

• Genotype Symbols

  • WT

  • heterozygous

  • homozygous

  • carrier (transgenes only)

  • noncarrier (transgenes only)

genotypeBackground

Genetic background of the model

• C57BL6J (#000664, JAX link)

• C57BL6N (#005304)

• C57BL6J:C57BL6N (#000664 & #005304)

• CC037 (#025423)

• CC041 (#021893)

• CC013 (#021892)

• CC006 (#022869)

• CC002 (#021236)

• CC017 (#022870)

• B6JCC037(#000664 & #025423)

• B6JCC041(#000664 & #021893)

• B6JCC013(#000664 & #021892)

• B6JCC006(#000664 & #022869)

• B6JCC002(#000664 & #021236)

• B6JCC017(#000664 & #02870)

• LOAD1--(#028709)

• LOAD2--(#030670)

individualCommonGenotype

Genotype of animal with LOAD

terminology (used by MODEL-AD Explorer)

LOAD1:

• APOE4_homozygous

• TREM2R47H_homozygous

LOAD2:

• APOE4_homozygous

• TREM2R47H_homozygous

• ABETA_homozygous
  

• LOAD1:

  • APOE4_homozygous

• • TREM2R47H_homozygous

• LOAD2:

  • APOE4_homozygous

  • TREM2R47H_homozygous

  • ABETA_homozygous

• C57BL6J

• 5XFAD

• APOE4

• Trem2R47H

• LOAD1.ABCA7A1527G

• LOAD1.CEACAM1KO

• LOAD1.CR1long

• LOAD1.Clasp2L163P

• LOAD1.Il1rapExon2KO

• LOAD1.MthfrC677T

• LOAD1.Plcg2M28L

• LOAD1.Snx1D465N

officialName

Official JAX Mice strain nomenclature.

Full name indicating all transgenes.

https://mice.jax.org

• C57BL/6J

• B6(SJL)-Apoe^{tm1.1(APOE*4)Adiuj} Trem2^em1Adiuj/J

modelSystemName

Strain annotation - see AMP-AD Metadata Dictionary. Used as file annotation

Abca7A1527GAPOE4Trem2R47H

See data query

stockNumber

The JAX stock number

030283