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These are the variables describing describe the mice in the Individual Metadata file. The modelSystemName is used as file annotation. The AD Model Explorer uses the LOAD definition.

Variable

Definition

Example

genotype

Genotype of animal that indicates littermate carriers vs noncarriers.

Format based on Climb variables: <gene>-<allele>_<genotypeSymbol>

  • APOE4-KI_heterozygous

  • APOE4-KI_homozygous

  • APOE4-KI_WT

  • 3xTg-AD_carrier

  • 3xTg-AD_noncarrier

officialName

Full name indicating all transgenes, taken from the strain’s JAX datasheet

  • B6.Cg-Apoetm1.1(APOE*4)Adiuj

  • Abca7em2Adiuj Trem2em1Adiuj/J

modelSystemName

Strain annotation - see AMP-AD Metadata Dictionary. Used as file annotation

Abca7A1527GAPOE4Trem2R47H

See data query

stockNumber

The JAX stock number

030283

genotypeBackground

Background genotype

C57BL6J

genotypeindividualCommonGenotype

Genotype of animal that indicates littermate carriers vs noncarriers

APOE4_homozygous; TREM2R47H_homozygous; ABCA7KI_NONCARRIER

APOE4_homozygous; TREM2R47H_homozygous; ABCA7KI_HOMOZYGOUS

individualCommonGenotype

Genotype of animal that includes LOAD1 or LOAD2 terminology. This is the model name used in the AD Model Explorerwith LOAD

terminology (used by MODEL-AD Explorer)

LOAD1:

  • APOE4_homozygous

  • TREM2R47H_homozygous

LOAD2:

  • APOE4_homozygous

  • TREM2R47H_homozygous

  • ABETA_homozygous

  • 5XFAD

  • APOE4

  • C57BL6J

  • LOAD1

  • LOAD1.ABCA7A1527G

  • LOAD1.CEACAM1KO

  • LOAD1.CR1long

  • LOAD1.Clasp2L163P

  • LOAD1.Il1rapExon2KO

  • LOAD1.MthfrC677T

  • LOAD1.Plcg2M28L

  • LOAD1.Snx1D465N

  • LOAD2

  • Trem2R47H

...