This article describes the procedure for how MODEL-AD teams should submit new mouse model information to the Sage AD Data Coordination Center (AD-DCC). Information about the model will be posted on the experimental tools page on the AD Knowledge Portal.
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Email address of the person submitting the survey
Grant number
Species
Model system name (see names in the AD Metadata Dictionary)
Model URL to Jax stock page (ex: https://www.jax.org/strain/031988)
Report card URL to AlzForum research model (ex: https://www.alzforum.org/research-models/3xtg)
Model description (<500 characters)
List of genes the model is targeting
Background strain (eg, C57BL/6J)
Type (LOAD – Late Onset Alzheimer’s Disease, FAD – Familial Alzheimer’s Disease)
At the bottom of the survey, you can upload a PDF of the mouse model reportMouse Model Report. The AD-DCC will add it to the Mouse Model Reports in Synapse.
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Step 2: AD-DCC adds model to the AD Knowledge Portal
The AD-DCC creates a new entity in Synapse’s Experimental Tools
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named after the Model
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System Name
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. This entity will annotated with the the information provided in the survey
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, including a link to
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the JAX stock page, and a list of studies that include data from the model.
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The AD-DCC will add the
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Mouse Model Report into the Mouse Model Reports in Synapse. Since the mouse model reports do not include sensitive information or PII/PHI, they are eligible for anonymous viewing and download permissions in Synapse. The Sage Governance team is responsible for enabling sharing permissions for each file in Synapse.
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Step 3: Creating release notes and advertising new models
The DCC writes release notes to inform AD-DCC informs the community when a new model is available . The release notes are posted in on the Portal in the AD Knowledge Portal News and link to the experimental tool in the AD Knowledge portal. FUTURE DIRECTION: When a new model is made available, the DCC will write a feature story about it for the newsletter. See past AD Knowledge Portal Public Data Release Notes.
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