This article describes the procedure for how MODEL-AD teams should submit new strain mouse model information to the Sage Data Coordination Center (DCC). Information about each new strain the model will be posted on the experimental tools page on the AD Knowledge Portal.
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Step 1: Submit information about mouse
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model through survey
Please provide information about the mouse strain in this MODEL-AD Tools survey. The strain information should match that on the JAX strain webpage.
Email address (person submitting the survey)
Grant number
Species (eg, Mouse)
Model Common Name as listed on the MODEL-AD Strain Table
Model URL to Jax strain page
ex: https://www.jax.org/strain/031988Report card URL to AlzForum strain
ex: https://www.alzforum.org/research-models/3xtgModel description (<500 characters)
List of genes the model is targeting
Background strain
Type (LOAD – Late Onset Alzheimer’s Disease, FAD – Familial Alzheimer’s Disease)
Submit a mouse strain report PDF. This report should be uploaded for question number X of the survey. The AD-DCC will add the strain report into the Mouse Model Reports in Synapse.
Step 2: DCC adds strain to the AD Knowledge Portal
The DCC creates a new file entity in Synapse’s Experimental Tools for the strain. The entity is named after the Model Common Name and will link to the JAX lab strain page.
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The AD-DCC will add the strain report into the Mouse Model Reports in Synapse. Since the mouse model reports do not include sensitive information or PII/PHI, they are eligible for anonymous viewing and download permissions in Synapse. The Sage Governance team is responsible for enabling sharing permissions for each file in Synapse.
Sage DCC updates file view with a link to the mouse model report in the Experimental Tools
Step 3: Creating release notes and advertising new strains
The DCC writes release notes to inform the community when a new strain is available. The release notes are posted in AD Knowledge Portal News and link to the experimental tool in the AD Knowledge portal.
DISCUSS OPTION w MODEL-AD TEAMS: When a new strain is available the DCC could write a feature story about it for the newsletter.
Past AD Knowledge Portal Public Data Release Notes.
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