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Documentation for how to provide information about new strains
This article describes the process procedure for how the MODEL-AD teams should submit new strain information . This information to the Data Coordination Center (AD-DCC). Information about each new strain will be posted in on the experimental tools page on the AD Knowledge Portal’s Data Coordination Center (AD-DCC)Portal .
Step 1: MODEL-AD submits information about the new strain
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MODEL-AD submits details through survey
Each strain should include the key details listed below. The model details should match the information on the Jax strain webpage, and any discrepancies will need to be resolved.
Email address for the person submitting the survey
MODEL-AD Grant number
Species
Model Common Name as used in the strain list listed on the MODEL-AD Strain Table
Model URL (link Jax strain page – ex: https://www.jax.org/strain/031988 )
Report card URL (link AlzForum strain, if available – ex: https://www.alzforum.org/research-models/3xtg )
Model description (<500 characters)
A list of genes the model is targeting
Background strain
Type (LOAD – Late Onset Alzheimer’s Disease, FAD – Familial Alzheimer’s Disease)
MODEL-AD
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submits strain report
The MODEL-AD data liaison team should provide the AD-DCC with this report somehow and at some interval….
Test and see if Google forms allows for attachments. We could capture the report at the same time.
The Sage a new strain report PDF. This report should be uploaded for question number X of the survey.
The AD-DCC will add the mouse model strain report into the Mouse Model Reports in Synapse.
Step 2: AD-DCC Adds new strain to the AD Knowledge Portal
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Add strain in Synapse
The AD-DCC creates a new file entity in Synapse’s Experimental Tools for the strain. The Synapse entity is named after the Model Common Name and will link to the Jax lab strain page.
Navigate to AD Knowledge Portal’s Experimental Tools page
Click Folder Tools > Add New Folder
Name the folder with the Model Common Name
Add a URL to the Jackson labs strain (eg, https://www.jax.org/strain/123456)
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Annotate strain
The AD-DCC annotates the model entity new strain with the content provided in the survey.
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Navigate to the Experimental Tools file view
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Link to
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all data files from strain
The AD-DCC creates a link to any study that includes data from the strain.
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AD-DCC sets necessary sharing permissions
Since the mouse model reports do not include sensitive information or PII/PHI, they are eligible for anonymous viewing and download permissions in Synapse. The Sage Governance team is responsible for enabling sharing permissions for each file in Synapse.
Sage DCC updates file view with link to model report
Sage DCC updates file view with a link to the mouse model report in the Experimental Tools
Step 3: Creating release notes and advertising new strains
The AD-DCC writes release notes to inform the community when a new strain is available. The release notes are posted in News stories and link to the experimental tool in the AD Knowledge portal. Additionally,
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