2013 DREAM 8 Challenges

We are pleased to announce that the DREAM8 Challenges are now open for participation. During the "Challenge season" spanning from June 10 to September 15, 2013, Sage Bionetworks and DREAM will run the three Challenges described below. Best performers in the DREAM8 Challenges will be invited to present at the DREAM conference (November 8-12, Toronto, Canada) with travel expenses covered by the Sage/DREAM organizers. Sage Bionetworks and DREAM are also working with high impact journals to ensure that the methodology developed by the Challenges' best performers will be considered for publication under the Challenge-assisted Peer Review format.

Click on a link below to read the Challenge detail and sign up for a Challenge.

HPN-DREAM Breast Cancer Network Inference Challenge

Participants in this Challenge will be provided with an extensive proteomics time-course dataset on four breast cancer cell lines and tasked with analyzing these data to solve the following 3 sub-challenges: 1) build network models that represent the active cell signaling pathways in breast cancer, 2) predict the dynamic response of various phospho-proteins to drug perturbations, and 3) propose novel strategies to visualize these high dimensional data.

NIEHS-NCATS-UNC DREAM Toxicogenetics Challenge

We will provide genetics and transcriptomics information of the 1000 Genomes Project (www.1000genomes.org), as well as cytotoxicity measures derived from compound exposure to over a hundred toxic agents using the 1000 genomes lymphoblastoid cell lines. Participants are tasked with solving two related subchallenges: (1) develop predictive models of cytotoxicity using genetic and genomic data to predict individual responses to compound exposure and (2) use chemical attributes to predict population-based cytotoxicity characteristics (median, variance) for a set of compounds.

The Whole-Cell Parameter Estimation DREAM Challenge

Participants will be provided with a whole cell model of Mycoplasma genitalium and tasked with estimating the model parameters for specific biological processes from simulated data. The simulated data to be provided represents possible measurements in actual experiments: participants will will have a credit budget and will be able to purchase simulated data on demand with the aim to refine the parameters under estimation.

Click here to sign up for Sage / DREAM8 challenge updates

About DREAM Challenges

Sage Bionetworks and DREAM are convinced that running open computational Challenges focused on important unsolved questions in systems biomedicine can help advance basic and translational science. By presenting the research community with well-formulated questions that usually involve complex data, we effectively enable the sharing and improvement of predictive models, accelerating many-fold the analysis of such data. The ultimate goal, beyond the competitive aspect of these Challenges, is to foster collaborations of like-minded researchers that together will find the solution for vexing problems that matter most to citizens and patients.

About Synapse

Synapse is an open computational platform designed to facilitate new ways for data scientists to work with data and with each other. Synapse reinforces the power of DREAM Challenges to catalyze a diverse community of researchers to nucleate around a particular scientific question. Synapse’s engaging features such as real-time leaderboards, code-sharing, and provenance tracking incentivize continuous participation in DREAM Challenges. Participants can accelerate scientific progress by generating, sharing, and evolving thousands of predictive models in real time that would have otherwise taken years to produce.

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