Study Organization and Documentation

Study Naming

MODEL-AD data and metadata are organized by site and study.

Study Description

Each study should be accompanied by a brief study description that includes the species, genetic background, a link to the Jax Datasheet (if available) or a description of how the animals were created.

Download the in-progress study description template.

Assay Description

Each assessment should be accompanied by a brief description with information about the assessment procedures, data generation and processing, and analytical methods. This information is often described in the Materials and Methods section of a manuscript. This is a good opportunity to clarify or provide additional detail that may not be included in the peer-reviewed manuscript.

TODO A methods description template will be made available here.

Issues to clarify include:

• File naming conventions

• Assay-specific examples. Need a list of most common assays.

  • RNA sequencing

  • Behavioral

  • Frailty

  • Open field

Study Organization

MODEL-AD Studies will be organized in Synapse with a directory schema similar to this:

• Study_name/

  • Assay_Type_1/ (data from first assay)

  • Assay_Type_2/ (data from second assay)

  • Metadata/

  • Staging/ (data that has yet to be released)

    • Assay_Type_n/ (unreleased data from nth assay)

Acknowledgement Statement

Every MODEL-AD study should include the following acknowledgment:

The results published here are in whole or in part based on data obtained from the AD Knowledge Portal ( https://adknowledgeportal.synapse.org/ ). The IU/JAX/UCI MODEL-AD Center was established with funding from The National Institute on Aging (U54 AG054345-01 and AG054349). Aging studies are also supported by the Nathan Shock Center of Excellence in the Basic Biology of Aging (NIH P30 AG0380770).