2013 DREAM 8 Challenges
We are pleased to announce that the DREAM8 Challenges listed below opened for participation on June 10, 2013 and will continue until September 15, 2013. Best performers in the DREAM8 Challenges will be invited to present at the DREAM conference (November 8-12, Toronto, Canada) with travel expenses covered by the Sage/DREAM organizers. Sage Bionetworks and DREAM are also working with high impact journals to ensure that the methodology developed by the Challenges' best performers will be considered for publication under the Challenge-assisted Peer Review format.
Click on a link below to read the Challenge detail and sign up for a Challenge.
HPN-DREAM Breast Cancer Network Inference Challenge
Participants in this Challenge will be provided with an extensive proteomics time-course dataset on four breast cancer cell lines and tasked with analyzing these data to solve the following 3 sub-challenges: 1) build network models that represent the active cell signaling pathways in breast cancer, 2) predict the dynamic response of various phospho-proteins to drug perturbations, and 3) propose novel strategies to visualize these high dimensional data.
NIEHS-NCATS-UNC DREAM Toxicogenetics Challenge
We will provide genetics and transcriptomics information of the 1000 Genomes Project (1000genomes.org), as well as cytotoxicity measures derived from compound exposure to over a hundred toxic agents using the 1000 genomes lymphoblastoid cell lines. Participants are tasked with solving two related subchallenges: (1) developing predictive models of cytotoxicity using genetic and genomic data to predict individual responses to compound exposure and (2) using chemical attributes to predict population-based cytotoxicity characteristics (median, variance) for unknown compounds.
The Whole-Cell Parameter Estimation DREAM Challenge
Participants will be provided with a whole cell model of Mycoplasma genitalium and tasked with estimating the model parameters from simulated data for specific biological processes. The simulated data to be provided represents possible measurements in actual experiments: participants will be able to purchase this on demand with the aim to refine the parameters under estimation.
About DREAM Challenges
Sage Bionetworks and DREAM are convinced that running open computational Challenges focused on important unsolved questions in systems biomedicine can help advance basic and translational science. By presenting the research community with well-formulated questions that usually involve complex data, we effectively enable the sharing and improvement of predictive models, accelerating many-fold the analysis of such data. The ultimate goal, beyond the competitive aspect of these Challenges, is to foster collaborations of like-minded researchers that together will find the solution for vexing problems that matter most to citizens and patients.
About Synapse
Synapse is an open computational platform intentionally designed to facilitate new ways for data analysts and DREAM Challenge participants to work with data and with each other. Synapse reinforces the power of DREAM Challenges to catalyze a diverse community of researchers to nucleate around a particular scientific Challenge and even makes it possible to run Challenges off of high dimensional human data. Synapse’s engaging features such as real-time leaderboards, code-sharing and provenance tracking incentivize continuous participation in DREAM Challenges and lead to the sharing of thousands of predictive models that would otherwise take years to produce using the usual siloed research paradigms.
DREAM8 Press Releases
Click here to read the Heritage Provider Network press release
Click here to read the April 19, 2013 DREAM8 Challenge press release.
DREAM-DEMO-J
This is for test purposes only
