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- Amplification of 19q13.1-q13.2 sequences in ovarian cancer. G-band, FISH, and molecular studies, 1996. By FISH showed structural abnormalities, amplification and overexpression of AKT2 oncogene.
Analyses of other correlated modules from the coexpression and comethylation (mb) networks. Is flanking a rule?
Here are few other graphs for the correlating coexpression and comethylation modules along with their stats (module size, overlap, overlap P value, correlation coefficient, association with survival). All Rho correlation coefficients are |Rho|=>0.4
Violet (Affy): size - 63, Cox P value - 0.83, major chromosome - X
Gold2 (mb): size - 27, Wald's P value - 0.24, major chromosome - X.
Overlap: 1, overlap P value: 0.079
Violetred (Affy): size - 53, Cox P value - 0.04, major chromosome - 13
Yellow4 (Affy): size - 26, Cox P value - 0.54, major chromosome - 13
Peru (mb): size - 134, Wald's P value - 0.059, major chromosome - 13.
Overlap (violetred vs peru): 16, overlap P value: 0
Overlap (yellow4 vs peru): 3, overlap P value: 0.54
Black (Affy): size - 133, Cox P value - 0.19, major chromosome - 9
Chocolate (mb): size - 109, Wald's P value - 0.026, major chromosome - 9.
Overlap: 24, overlap P value: 0
Pink (Affy): size - 121, Cox P value - 0.18, major chromosome - 17
Firebrick (mb): size - 53, Wald's P value - 0.5, major chromosome - 17.
Overlap: 4, overlap P value: 0.002
Greenyellow (Affy): size - 109, Cox P value - 0.74, major chromosome - 16
Forestgreen (mb): size - 91 , Wald's P value - 0.47, major chromosome - 16.
Overlap: 12, overlap P value: 0
It seems to me that flanking of coexpression modules with comethylation modules correlated with them is not a rule. What I see is that CpG sited from cometh. module are sprinkled over regions of general clustering of the coexpressed genes.