Here I will show results of the univariate analysis of correlation of DNA methylation with clinical traits such as survival, days to tumor recurrence, tumor stage, tumor grade, age, primary therapy outcome and tumor residual disease.
Survival
P value | # of targets | FDR |
|---|---|---|
0.001 | 5 |
|
0.005 | 46 |
|
0.01 | 107 |
|
0.05 | 859 |
|
Method: Cox Proportional Hazards model, P values = Wald's test. This distribution of P values concerns me. If I had no signal the distribution would be rather uniform rather than skewed towards 1. I think it might mean that I have some normalization issues (need to show this plot to Brig)
Days to tumor recurrence
P value | # of targets | FDR |
|---|---|---|
0.001 | 27 |
|
0.005 | 149 |
|
0.01 | 302 |
|
0.05 | 1543 |
|
Method: Cox Proportional Hazards model, P values = Wald's test.
Primary therapy outcome
Method: Kruskal Wallis test
P value | # of targets | FDR |
|---|---|---|
0.001 | 19 |
|
0.005 | 111 |
|
0.01 | 205 |
|
0.05 | 1128 |
|