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Dataset

# Probes

# Samples

Sage Time

Sage Space

Package Time

Package Space

Sage beta

Package beta

Gene trees same, independent beta?

Gene trees same, same beta?

Module difference***, independent beta

Module difference***, same beta

Female mouse liver

3600

135

---

---

---

---

6.5

6.5

TRUE

TRUE

3.7%

3.7%

Cranio

2534

249

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---

---

---

4.0

4.5

FALSE

TRUE

44%

0.9%

Methylation, top 5K genes

5000

555

---

---

---

---

8.5

8.5

TRUE

TRUE

0

0

Colon cancer, top 5K genes

5000

322

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3

3.5

FALSE

TRUE

11%

0.5%

Human liver cohort, top 5K genes

5000

427

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11

11

TRUE

TRUE

1.0%

1.0%

PARC*

18,392

960

5h:55m

83.9 GB

1h:40m

71 GB

8

7.5

FALSE

FALSE

4.7%

0.6%

Methylation (full set)*

27,578

555

24h:45m

180 GB

6h:38m

196 GB

8

11.5

FALSE

FALSE

14%

0.2%

Colon cancer, top 40K genes*

40,000

322

Out of memory**

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Out of memory  after 16h:12m**

276 GB

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Human liver cohort*

40,102

427

Out of memory**

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Out of memory after 16h:46m**

276 GB

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** Note:  UCLA-WGCNA package also runs out of memory.  (An alternative is to use the WGCNA preprocessing step of K-means decomposition, which has been shown to work with >50K genes.)

*** http://florence.acadiau.ca/collab/hugh_public/index.php?title=R:compare_partitions

Note: We skip the performance evaluation for the small data sets.

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