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We are trying to evaluate which method is the most appropriate for normalization. Here we are going to compare each method "performance" by identifying the number of loci associated with age and finding an overlap and associated P-values with each overlap. The top right triangle represents the overlap and the bottom left triangle represents the significance of overlap (P-values)
| Level 2 | Level 1 - lumi | snm (meth.probes only) | Teschendorff, 2010 |
|---|---|---|---|---|
Level 2 |
| 1689 | NA | 101 |
Level 1 - lumi | 0 |
| NA | 89 |
snm (meth.probes only) | NA | NA |
| NA |
Teschendorff, 2010 | 2.261381e-11 | 1.763328e-09 | NA |
|
Overlap between level 1- lumi/Teschendorff, 2010 and level 2/Teschendorff, 2010 is 75.