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Synapse is an open computational platform designed to facilitate new ways for data scientists to work with data and with each other. Synapse reinforces the power of DREAM Challenges to catalyze a diverse community of researchers to nucleate around a particular scientific question. Synapse’s engaging features such as real-time leaderboards, code-sharing, and provenance tracking incentivize continuous participation in DREAM Challenges. Participants can accelerate scientific progress by generating, sharing, and evolving thousands of predictive models in real time that would have otherwise taken years to produce.