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HPN-DREAM Breast Cancer Network Inference Challenge
Click here to read the Heritage Provider Network press release
Sponsored by the Heritage Provider Network (HPN) and the NCI Division of Cancer Biology, and in collaboration with the labs of Drs. Joe Gray and Paul Spellman from the Oregon Health and Science University, and Dr. Sach Mukherjee from the Netherlands Cancer Institute, Sage Bionetworks and DREAM are running the Heritage-DREAM Breast Cancer Network Inference Challenge in 2013. This Challenge will build upon the lessons extracted from the NCI-DREAM Challenge, run by DREAM in 2012 (with the full support of the NCI Division of Cancer Biology). In that 2012 Challenge, the work of over 50 teams throughout the 4-month Challenge period rigorously showed the feasibility to predict the sensitivity of 18 mammary cancer cell lines to 35 different therapeutic agents. However, many improvements in model prediction are still needed to make these models valuable in a clinical or drug discovery setting.
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National Brain Tumor Society – DREAM Cancer Prediction Challenge
Click here to read the National Brain Tumor Society Press Release
Sponsored by the National Brain Tumor Society (NBTS), this Challenge aims to predictin vivo drug activity on glioblastoma tumors. The Challenge will be organized by Sage Bionetworks and DREAM, and jointly led by experts from the National Brain Tumor Society (NTBS), Columbia University and others. The Challenge will invite participants to predict the specific drugs and drug combinations that will elicit the strongest therapeutic response in mice orthotopically transplanted with human high grade gliomas, based on their baseline genomic characterization. Relevant data, including baseline GBM related molecular profiles from TCGA, molecular profiles of mouse xenografts for which drug activity will be inferred, and baseline drug response in GBM related lines, from the cancer cell line encyclopedia (CCLE), will be hosted on a compute platform along with the participants’ code for their models. This will allow teams to have credit for sharing their ideas and models thereby accelerating insights before publication. Existing data will be made publicly available to the research community for the assembly and interrogation of GBM models to participate in this Challenge.
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As in the other challenges, the best performing team will be invited to present at the DREAM conference with travel expenses covered. Sage/DREAM organizers are also working with high impact journals to ensure that the best performer methodology could be considered for publication under the challenge-assisted peer review format.
DREAM8 Press Releases
Click here to read the April 19, 2013 DREAM8 Challenge press release.
Click here to to be contacted when the DREAM8 Challenges open for competition.
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