Page Comparison

This checklist

• FUNDING AGENCY

• NF-OSI DCC (Sage Bionetworks)

• SOW-REVIEWER (Sage Bionetworks)

• AWARDEE (PI)

Award and Milestones:

1. NTAP : Generate and the PI draft a statement of work (SOW) with tentative milestones and expected upload of key data. This process will be ~ 95% complete until Sage is involved.

2. NTAP: Send sends preliminary SOW to Sage with the following required information(not the final version, but one step prior to final) to NF-OSI DCC.

   1. The following information is required:

      1. Project name

      and

      1. , PI, Institution, DOI Link

      2. Milestone start and due dates

      3. Overview of the Aims

      4. For each

      milestone

      1. experiment within the milestones:

      2. Description of the experiment included in an Aim

      3. Name of the assay being performed

      4. Number of samples in that assay

      5. Species used for the assay

      6. Whether protocol for the assay is needed: Yes/No

         1. Name of the assay (i.e. RNA sequencing, MRI-imaging, proteomics, etc)

         2. Short description of the experiment (i.e. Performing RNA sequencing on cutaneous neurofibromas extracted from patients with x treatment, etc.)

         3. Number of samples (i.e. number of patients, animal models, etc.)

         4. Species (i.e. human, mouse, etc)

         5. If protocol is required to upload: [Yes or No]

3. Sage:SOW-reviewer : Review review preliminary SOW to identify key datasets that can be uploaded to Synapse. Key datasets generally fulfill one or more of the following criteria:

   1. Dataset follows the “required” criteria for sharing as noted by the NF research community

   2. Dataset contains more than 20 samples in the dataset or generated from patient samples (N > 5)

   3. Dataset contains data generated using high-throughput methods that output raw data presented in a widely used systematic format (for example: WGS, WES, RNA-seq, scRNAseq, whole slide imaging, MRI, spatial transcriptomics, spatial biology, spatial 'omics, plate-based drug screening, automated multiplexed imaging, etc.)

   4. Omics data derived from unbiased techniques

   5. Dataset considered to be validation data for a new method that is being developed in the funded grant  (see an example here)

   6. Dataset considered to be of interest to the funding partner (see an example here)

4. Sage: SOW-reviewer: Identifies required key datasets and fills out a form on https://dsp.nf.synapse.org/ to pre-fill the table outlining the Milestones, folder name, data description, and upload date. The unique reference ID of the study should be according to the following convention - “Initiative-<Awardee-name>-YYYY” and submit. Any optional datasets identified in the SOW should be called out in comments in the SOW during review. NTAP and PI should decide if the optional datasets should be added to the data sharing plan (DSP).

5. Sage:NF-OSI DCC: Once form is submitted by the SOW-reviewer, start the internal review of the pre-filled DSP.

6. Sage: SOW-reviewer: After internal approval, collate reviewed SOW and the pre-filled DSP (word document) into a packet and send to both NTAP and the PI.

7. PI updates the DSP form on the weblink.

   1. Required:

      1. Add the section that explains what the pre-filled DSP is

      2. Add the DSP with highlights noting what needs to be updated by the recipient (AWARDEE PI)

8. Sage: SOW-reviewer: Archive the reviewed SOW+pre-filled DSP packet on the internal Sage-NTAP drive

9. NTAP: Email finalized SOW + pre-filled DSP to the awardee and respond to awardee’s questions or concerns regarding the SOW.

10. NTAP: Iterates over the SOW and pre-filled DSP with AWARDEE (PI) to finalize the data sharing plan.

11. NTAP: Once data sharing plan is final between NTAP and AWARDEE (PI), NTAP asks AWARDEE (PI) to update final changes to the DSP using the web-link provided on the pre-filled DSP.

12. NTAP: Send final SOW to Sage as confirmation

13. Sage:NF-OSI DCC: Review the final DSP form filled by the AWARDEE (PI) on the webform and confirm When the PI fills out the form, Sage will be updated via GitHub and will confirms that all required fields (e.g. governance etc) are filled properly. Sage:NF-OSI DCC: Once everything is filled out, generate the executed Data Sharing Plan for the project in PDF format and send it to NTAP and AWARDEE (PI) for the records.

14. NTAP: Sends sends an award letter to AWARDEE (PI) after confirming the SOW and introduces Sage to the awardee. The introductory email includes the following:

    1. Role of Sage and Synapse in data upload as expected for the NTAP award

    2. Expectation of Data Sharing plan to be filled with the tables in SOW and sent to Sage to start the project intake process

    3. Expected embargo end date for data release for the project

    Proposal central DOI for the awarded project

15. NTAP sends the final SOW to Sage.

Synapse Study Creation/ Project Intake:

1. Sage: NF-OSI DCC: Follows up on the introductory email with information :

   • Pre-filled data sharing plan for the awardee to sign and upload to the Project Intake Form (Step 14 above)

   • Filling out the Project Intake form as described in NF Data Portal’s documentation page

   Sage: NF-OSI DCC: Send email to AWARDEE (PI) confirming the following

   • Established Synapse project space with link to access the project

   • Link to the final DSP uploaded to a folder in the Synapse project

   • Link to Study page in NF Data Portal 

   • Sets Study Status to “Active”Uploads the final data sharing plan to the project space in a folder named “Admin”

For projects

• studyName

• studyId

• summary

• initiative

• studyLeads

• institutions

• manifestation

• diseaseFocus

• studyStatus

• dataStatus

• fundingAgency

• accessRequirements

• acknowledgementStatements

• dataType

• relatedStudies

• studyFileviewId

• id

• grantDOI

• Resource_id