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Study type

How many strains?

Naming convention

Example names

Primary screen

Many

Site_PrimaryScreen

  • Jax.IU.Pitt_PrimaryScreen

  • UCI_PrimaryScreen

Strain validation

Many

Site_StrainValidation

  • Jax.IU.Pitt_StrainValidation

  • UCI_StrainValidation

Deep phenotyping

One

Site_Model

  • Jax.IU.Pitt_APOE4_Trem2

  • UCI_5XFAD

Pharmacokinetic (PK)

One

Site_Model_Drug

  • Jax.IU.Pitt_5XFAD_Verubecestat

Pilot Studies

  • Microbiome

  • Proteomics and Metabolomics

Many

Site_StudyType_Pilot

  • Jax.IU.Pitt_MicrobiomePilot Link

  • Jax.IU.Pitt.Proteomics_Metabolomics_Pilot Link

Study

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MODEL-AD Studies are usually organized with directories as follows:

  • Study_name/

    • Assay_Type_1/ (data from first assay)

    • Assay_Type_2/ (data from second assay)

    • Metadata/

    • Staging/ (data that has yet to be released)

      • Assay_Type_n/ (unreleased data from nth assay)

Study Description

Each study should be accompanied by a brief study description that includes the species, genetic background, a link to the Jax Datasheet (if available) or a description of how the animals were created.

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  • File naming conventions

  • Assay-specific examples. Need a list of most common assays.

    • RNA sequencing

    • Behavioral

    • Frailty

    • Open field

Study Organization

MODEL-AD Studies will be organized in Synapse with a directory schema similar to this:

  • Study_name/

    • Assay_Type_1/ (data from first assay)

    • Assay_Type_2/ (data from second assay)

    • Metadata/

    • Staging/ (data that has yet to be released)

      • Assay_Type_n/ (unreleased data from nth assay)

Acknowledgement Statement

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